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Журнал "Клиническая геронтология"

ЭПИДЕМИОЛОГИЯ  И ФАКТОРЫ РИСКА ИШЕМИЧЕСКОГО КОЛИТА (Обзор)
С.В. Левченко
ГБОУ ВПО Московский государственный медико-стоматологический университет им.  А.И. Евдокимова  Минздрава России

Представлены современные данные о распространенности, патофизиологии и факторах риска ишемического колита (ишемической колопатии) как одной из наиболее распространенных патологий толстой кишки у пожилых в соответствии с клиническими рекомендациями по ишемическому поражению кишки Американской коллегии гастроэнтерологов (2015).
Ключевые слова:ишемический колит, эпидемиология, пожилой возраст, факторы риска, ишемия толстой кишки
Авторы заявляют об отсутствии возможных конфликтов интересов

EPIDEMIOLOGY AND  RISK FACTORS OF COLON ISCHEMIA (Review)
S.V.  Levchenko
Moscow state medical dentistry University n.a. A.I. Evdokimov

The literature review presents modern data on the prevalence, pathophysiology, risk factors of ischemic colitis (colon ischemia)  according to clinical guidelines for colon ischemia of the American College of gastroenterologists (2015) .
Key words: ischemic colitis, colon ischemia, elderly, epidemiology, risk factors
Author declare lack of the possible conflicts of  interests
                                             
Литература

  1. Lawrence J. Brandt, MD, MACG, AGAF, FASGE , Paul Feuerstadt, MD, FACG , George F. Longstreth, MD, FACG, AGAF  and Scott J. Boley, MD, FACS ACG Clinical Guideline: Epidemiology, Risk Factors, Patterns of Presentation, Diagnosis, and Management of Colon Ischemia (CI). Am. J .Gastroenterol. 2015; 110:18-44; doi:10.1038/ajg.2014.395.
  2. Hreinsson J.P., Gumundsson S., Kalaitzakis E. et al. Lower gastrointestinal bleeding: incidence, etiology, and outcomes in a population-based setting. Eur. J. Gastroenterol. Hepatol. 2013;25:37-43.
  3. Arroja B., Cremers I. , Ramos R. et al. Acute lower gastrointestinal bleeding management in Portugal: a multicentric prospective 1-year survey. Eur. J. Gastroenterol. Hepatol. 2011 ; 23 : 317 - 22 .
  4. Longstreth G.F. Epidemiology and outcome of patients hospitalized with acute lower gastrointestinal hemorrhage: a population-based study. Am. J. Gastroenterol. 1997 ; 92 : 419 – 24.
  5. Brandt L.J., Feuerstadt P., Blaszka M.C. Anatomic patterns, patient charac-teristics, and clinical outcomes in ischemic colitis: a study of 313 cases supported by histology. Am .J. Gastroenterol. 2010;105:2245-2252;quiz 2253.
  6. Suh D.C., Kahler K.H. , Choi I.S. et al. Patients with irritable bowel syndrome or constipation have an increased risk for ischaemic colitis. Aliment Pharmacol Ther. 2007;25:681-692.
  7. Longstreth G.F., Yao J.F. Epidemiology, clinical features, high-risk factors, and outcome of acute large bowel ischemia. Clin. Gastroenterol. Hepatol. 2009;7:1075-80.e1071-1072; quiz 1023.
  8. Ganguli K., Tanpowpong P., Katz A. Abdominal pain after hypovolemic shock in a 5-year old boy. Clin. Pediatr. 2012;51:1202-1204.
  9. Yanagisawa A., Namai Y., Sekine T. et al. Ischemic colitis as a complication in a patient with steroid-dependent nephrotic syndrome. Pediatr. Nephrol. 2008 ; 23 : 655 – 657.
  10.  Cole J., Cook S., Sands B. et al. Occurrence of colon ischemia in relation to irritable bowel syndrome. Am. J. Gastroenterol. 2004 ; 99 : 486 -4 91 .
  11.  Walker A., Bohn R., Cali C. et al. Risk factors for colon ischemia. Am. J. Gastroenterol. 2004 ; 99 : 1333 -1337 .
  12. Chang L. , Kahler K.H. , Sarawate C. et al. Assessment of potential risk factors associated with ischaemic colitis . Neurogastroenterol. Motil. 2008 ; 20 : 36 - 42
  13. Sotiriadis J., Brandt L., Behin D. et al. Ischemic colitis has a worse prog¬nosis when isolated to the right side of the colon. Am. J. Gastroenterol. 2007;102:2247-2252.
  14. Montoro M.A., Brandt L.J., Santolaria S. et al. Clinical patterns and outcomes of ischaemic colitis: results of the Working Group for the Study of Ischae¬mic Colitis in Spain (CIE study). Scand. J. Gastroenterol. 2011;46:236-246.
  15. Paterno F., McGillicuddy E.A. , Schuster K.M. et al. Ischemic colitis: risk factors for eventual surgery. Am. J. Surg. 2010 ; 200 : 646 - 650 .
  16.  Cubiella Fernandez J., Nunez Calvo L., Gonzalez Vazquez E. et al. Risk factors associated with the development of ischemic colitis. World. J. Gastroenterol. 2010;16:4564-4569.
  17. Heyn J., Buhmann S. , Ladurner R. et al. Recurrent ischemic colitis in a pa-tient with leiden factor V mutation and systemic lupus erythematous with antiphospholipid syndrome. Eur .J .Med. Res. 2008 ; 13 : 182 -184 .
  18.  Scheppach W., Langenfeld H., Schultz G., Wittenberg G., Hahn D., Kochsiek K. Nonobstructive mesenteric ischemia--a diagnostic problem in internal intensive care. Z. Gastroenterol. 1995 Apr;33(4):214-218.
  19. Bassem M. Chehab, M.D. , Edgard Wehbe, M.D. ,Imad I. Nassif, M.D. Non-Occlusive Mesenteric Ischemia . Kansas Journal of Medicine. 2008; 49:52.
  20. Abhijeet Dhoble*, Kamakshi Patel and Atul Khasnis, Non-occlusive mesenteric ischemia leading to 'pneumatosis intestinalis': a series of unfortunate hemodynamic events. Cases J. 2008, 1:60  doi:10.1186/1757-1626-1-60.
  21. Kazui T., Yamasaki M., Abe K., Watanabe S., Kawazoe K. Non-obstructive mesenteric ischemia: a potentially lethal complication after cardiovascular surgery: report of two cases. Ann Thorac. Cardiovasc. Surg. 2012;18(1):56-60.
  22. Schuler J.G., Hudlin M.M. Coecal necrosis: infrequent variant of ischemic colitis. Report of five cases. Dis Colon. Rectum .2000;43:708-712.
  23. Peter B.F. Mensink J., Leon M.  Moons, Ernst J. Kuipers. Chronic. gastrointestinal ischaemia: shifting paradigms. Gut. 2011;60:722-737.
  24. Yadav S. , Dave M ., Varayil J.E. et al. A population-based study of incidence, risk factors, clinical spectrum, and outcomes of ischemic colitis. Clin. Gastroenterol. Hepatol .2014 ; e-pub ahead of print 12 August 2014 . ISSN:  1542-7714.
  25. Beppu K. , Osada T., Nagahara A. et al. Relationship between endoscopic findings and clinical severity in ischemic colitis. Intern. Med. 2011;50:2263-2267.
  26. Lee T.C., Wang H.P., Chiu H.M. et al. Male gender and renal dysfunction are predictors of adverse outcome in nonpostoperative ischemic colitis patients . J. Clin. Gastroenterol. 2010 ; 44 : 96 - 100 .
  27. Flobert C. , Cellier C. , Berger A. et al. Right colonic involvement is associated with severe forms of ischemic colitis and occurs frequently in patients with chronic renal failure requiring hemodialysis. Am. J. Gastroenterol .2000 ; 95 : 195 -19 8 .
  28. Koutroubakis I.E., Sfiridaki A., Theodoropoulou A. et al. Role of acquired and hereditary thrombotic risk factors in colon ischemia of ambulatory patients . Gastroenterology. 2001 ; 121 : 561 -56 5 .
  29. Midian-Singh R., Polen A. , Durishin C. et al. Ischemic colitis revisited: a prospective study identifying hypercoagulability as a risk factor. South. Med. J. 2004 ; 97 : 120 -12 3 .
  30. Perry R.J., Martin M.J., Eckert M.J. et al. Colonic ischemia complicating open vs endovascular abdominal aortic aneurysm repair. J. Vasc .Surg. 2008 ; 48 : 272 - 277 .
  31. Champagne B.J., Lee E.C., Valerian B. et al. Incidence of colonic ischemia after repair of ruptured abdominal aortic aneurysm with endograft. J. Am .Coll .Surg. 2007 ; 204 : 597 – 602.
  32. Elramah M., Einstein M., Mori N. et al. High mortality of cocaine-related ischemic colitis: a hybrid cohort/case-control study. Gastrointest. Endosc .2012 ; 75 : 1226 - 1232 .
  33. Комиссаренко И.А. Коррекция дислипидемии у больтных старческого возраста. Клин. геронтол. 2016 ; 1:
  34. Ю.В. Конев. Паллиативная помощь в гериатрии. Клин. геронтол. 2016; 1:

References

1.Lawrence J. Brandt, MD, MACG, AGAF, FASGE , Paul Feuerstadt, MD, FACG , George F. Longstreth, MD, FACG, AGAF  and Scott J. Boley, MD, FACS ACG Clinical Guideline: Epidemiology, Risk Factors, Patterns of Presentation, Diagnosis, and Management of Colon Ischemia (CI). Am. J .Gastroenterol. 2015; 110:18-44; doi:10.1038/ajg.2014.395.
2.Hreinsson J.P., Gumundsson S., Kalaitzakis E. et al. Lower gastrointestinal bleeding: incidence, etiology, and outcomes in a population-based setting. Eur. J. Gastroenterol. Hepatol. 2013;25:37-43.
3.Arroja B., Cremers I. , Ramos R. et al. Acute lower gastrointestinal bleeding management in Portugal: a multicentric prospective 1-year survey. Eur. J. Gastroenterol. Hepatol. 2011 ; 23 : 317 - 22 .
4.Longstreth G.F. Epidemiology and outcome of patients hospitalized with acute lower gastrointestinal hemorrhage: a population-based study. Am. J. Gastroenterol. 1997 ; 92 : 419 – 24.
5.Brandt L.J., Feuerstadt P., Blaszka M.C. Anatomic patterns, patient charac-teristics, and clinical outcomes in ischemic colitis: a study of 313 cases supported by histology. Am .J. Gastroenterol. 2010;105:2245-2252;quiz 2253.
6.Suh D.C., Kahler K.H. , Choi I.S. et al. Patients with irritable bowel syndrome or constipation have an increased risk for ischaemic colitis. Aliment Pharmacol Ther. 2007;25:681-692.
7.Longstreth G.F., Yao J.F. Epidemiology, clinical features, high-risk factors, and outcome of acute large bowel ischemia. Clin. Gastroenterol. Hepatol. 2009;7:1075-80.e1071-1072; quiz 1023.
8.Ganguli K., Tanpowpong P., Katz A. Abdominal pain after hypovolemic shock in a 5-year old boy. Clin. Pediatr. 2012;51:1202-1204.
9.Yanagisawa A., Namai Y., Sekine T. et al. Ischemic colitis as a complication in a patient with steroid-dependent nephrotic syndrome. Pediatr. Nephrol. 2008 ; 23 : 655 – 657.
10. Cole J., Cook S., Sands B. et al. Occurrence of colon ischemia in relation to irritable bowel syndrome. Am. J. Gastroenterol. 2004 ; 99 : 486 -4 91 .
11. Walker A., Bohn R., Cali C. et al. Risk factors for colon ischemia. Am. J. Gastroenterol. 2004 ; 99 : 1333 -1337 .
12.Chang L. , Kahler K.H. , Sarawate C. et al. Assessment of potential risk factors associated with ischaemic colitis . Neurogastroenterol. Motil. 2008 ; 20 : 36 - 42
13.Sotiriadis J., Brandt L., Behin D. et al. Ischemic colitis has a worse prog¬nosis when isolated to the right side of the colon. Am. J. Gastroenterol. 2007;102:2247-2252.
14.Montoro M.A., Brandt L.J., Santolaria S. et al. Clinical patterns and outcomes of ischaemic colitis: results of the Working Group for the Study of Ischae¬mic Colitis in Spain (CIE study). Scand. J. Gastroenterol. 2011;46:236-246.
15.Paterno F., McGillicuddy E.A. , Schuster K.M. et al. Ischemic colitis: risk factors for eventual surgery. Am. J. Surg. 2010 ; 200 : 646 - 650 .
16. Cubiella Fernandez J., Nunez Calvo L., Gonzalez Vazquez E. et al. Risk factors associated with the development of ischemic colitis. World. J. Gastroenterol. 2010;16:4564-4569.
17.Heyn J., Buhmann S. , Ladurner R. et al. Recurrent ischemic colitis in a pa-tient with leiden factor V mutation and systemic lupus erythematous with antiphospholipid syndrome. Eur .J .Med. Res. 2008 ; 13 : 182 -184 .
18. Scheppach W., Langenfeld H., Schultz G., Wittenberg G., Hahn D., Kochsiek K. Nonobstructive mesenteric ischemia--a diagnostic problem in internal intensive care. Z. Gastroenterol. 1995 Apr;33(4):214-218.
19.Bassem M. Chehab, M.D. , Edgard Wehbe, M.D. ,Imad I. Nassif, M.D. Non-Occlusive Mesenteric Ischemia . Kansas Journal of Medicine. 2008; 49:52.
20.Abhijeet Dhoble*, Kamakshi Patel and Atul Khasnis, Non-occlusive mesenteric ischemia leading to 'pneumatosis intestinalis': a series of unfortunate hemodynamic events. Cases J. 2008, 1:60  doi:10.1186/1757-1626-1-60.
21.Kazui T., Yamasaki M., Abe K., Watanabe S., Kawazoe K. Non-obstructive mesenteric ischemia: a potentially lethal complication after cardiovascular surgery: report of two cases. Ann Thorac. Cardiovasc. Surg. 2012;18(1):56-60.
22.Schuler J.G., Hudlin M.M. Coecal necrosis: infrequent variant of ischemic colitis. Report of five cases. Dis Colon. Rectum .2000;43:708-712.
23.Peter B.F. Mensink J., Leon M.  Moons, Ernst J. Kuipers. Chronic. gastrointestinal ischaemia: shifting paradigms. Gut. 2011;60:722-737.
24.Yadav S. , Dave M ., Varayil J.E. et al. A population-based study of incidence, risk factors, clinical spectrum, and outcomes of ischemic colitis. Clin. Gastroenterol. Hepatol .2014 ; e-pub ahead of print 12 August 2014 . ISSN:  1542-7714.
25.Beppu K. , Osada T., Nagahara A. et al. Relationship between endoscopic findings and clinical severity in ischemic colitis. Intern. Med. 2011;50:2263-2267.
26.Lee T.C., Wang H.P., Chiu H.M. et al. Male gender and renal dysfunction are predictors of adverse outcome in nonpostoperative ischemic colitis patients . J. Clin. Gastroenterol. 2010 ; 44 : 96 - 100 .
27.Flobert C. , Cellier C. , Berger A. et al. Right colonic involvement is associated with severe forms of ischemic colitis and occurs frequently in patients with chronic renal failure requiring hemodialysis. Am. J. Gastroenterol .2000 ; 95 : 195 -19 8 .
28.Koutroubakis I.E., Sfiridaki A., Theodoropoulou A. et al. Role of acquired and hereditary thrombotic risk factors in colon ischemia of ambulatory patients . Gastroenterology. 2001 ; 121 : 561 -56 5 .
29.Midian-Singh R., Polen A. , Durishin C. et al. Ischemic colitis revisited: a prospective study identifying hypercoagulability as a risk factor. South. Med. J. 2004 ; 97 : 120 -12 3 .
30.Perry R.J., Martin M.J., Eckert M.J. et al. Colonic ischemia complicating open vs endovascular abdominal aortic aneurysm repair. J. Vasc .Surg. 2008 ; 48 : 272 - 277 .
31.Champagne B.J., Lee E.C., Valerian B. et al. Incidence of colonic ischemia after repair of ruptured abdominal aortic aneurysm with endograft. J. Am .Coll .Surg. 2007 ; 204 : 597 – 602.
32.Elramah M., Einstein M., Mori N. et al. High mortality of cocaine-related ischemic colitis: a hybrid cohort/case-control study. Gastrointest. Endosc .2012 ; 75 : 1226 - 1232 .
33.Komissarenko IA Correction of dyslipidemia in elderly boltnyh. Wedge. Gerantol. 2016; 1: (In Russ.).
34. Y. Konev. Palliative care in geriatrics. Wedge. Gerantol. 2016; 1: (In Russ)



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